Pharmacological hyperprolactinaemia

Hyperprolactinaemia.

Hyperprolactinaemia is a frequent cause of reproductive problems encountered in clinical practice. A variety of pathophysiological conditions can lead to hyperprolactinaemia; therefore, pregnancy, drug effects, hypothyroidism and polycystic ovary syndrome should be excluded before investigating for prolactin-secreting pituitary tumours. Prolactinomas are mainly diagnosed in women aged 20-40 yea...

Macroprolactin and hyperprolactinaemia.

The recent report on “macroprolactin and hyperprolactinaemia” is very interesting. Jamaluddin et al. noted that 4.4 % of the patients have macroprolactin and concluded that “macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment.” Similar to many other “macro” phenomenon (macroCK, macroamylase, etc.), the macroprolactin can result in aberra...

Hyperprolactinaemia in primary Sjögren's syndrome.

Hyperprolactinaemia: metabolic consequences

Prolactin (PRL) is an anterior pituitary hormone first identified in 1933. PRL is secreted in a pulsatile fashion and is under chronic inhibition by dopamine. Hyperprolactinaemia is the most common disorder of the hypothalamic-pituitary axis. Chronic excess of prolactin disrupts the normal pulsatile secretion of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) and follicle-sti...

Hyperprolactinaemia with amisulpride.

Psychopharmaca are used in treatment of psychiatric illnesses and disorders, among other therapeutic possibilities. The choice of the psychopharmaca is determined by the specific psychopathology of the patient, within the diagnostic categories, according to the current classification of diseases and disorders. With the advances in pharmaco industry, the range of drugs used in the everyday clini...